Supporting Information ”Interleukin-1β enhances FasL-induced caspase-3/-7 activity without increasing apoptosis in primary mouse hepatocytes”
نویسندگان
چکیده
1 Department of Pharmaceutical Biology and Biotechnology, Albert Ludwigs University Freiburg, Stefan-Meier-Str. 19, 79104 Freiburg, Germany 2 Institute for System Dynamics, University of Stuttgart, 70550 Stuttgart, Germany 3 Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Auerbachstr. 112, 70376 Stuttgart, Germany 4 Institute of Molecular Medicine and Cell Research, Albert Ludwigs University Freiburg, Stefan-Meierstr. 17, 79104 Freiburg, Germany 5 Spemann Graduate School of Biology and Medicine (SGBM), Albert Ludwigs University Freiburg, Albertstr. 19a, 79106 Freiburg, Germany 6 Bioss Centre for Biological Signaling Studies, Albert Ludwigs University Freiburg, Albertstr. 19, 79106 Freiburg, Germany
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Interleukin-1β Enhances FasL-Induced Caspase-3/-7 Activity without Increasing Apoptosis in Primary Mouse Hepatocytes
Sustained inflammation may increase the susceptibility of hepatocytes to apoptotic cell death and therefore exacerbate liver damage. Here we report that the pro-inflammatory cytokine IL-1β sensitizes primary murine hepatocytes to Fas ligand (FasL)-induced caspase-3/-7 activity. This process was dependent on JNK1/2 and the BH3-only proteins Bim and Bid. Mathematical modeling revealed that incuba...
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